This paper describes LISN's submissions to two shared tasks at WMT'21. For the biomedical translation task, we have developed resource-heavy systems for the English-French language pair, using both out-ofdomain and in-domain corpora. The target genre for this task (scientific abstracts) corresponds to texts that often have a standardized structure. Our systems attempt to take this structure into account using a hierarchical system of sentence-level tags. Translation systems were also prepared for the News task for the French-German language pair. The challenge was to perform unsupervised adaptation to the target domain (financial news). For this, we explored the potential of retrieval-based strategies, where sentences that are similar to test instances are used to prime the decoder.